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KMID : 0383820080640020102
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Tuberculosis and Respiratory Diseases
2008 Volume.64 No. 2 p.102 ~ p.108
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A Trial of Aerosolized Colistin for the Treatment of Nosocomial Pneumonia due to Multidrug-resistant Acinetobacter baumannii
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Kim Chang-Hwan
Kim Dong-Gyu
Kang Hae-Raen
Choi Jeong-Hee
Lee Chang-Youl
Hwang Yong-Il
Shin Tae-Rim
Park Sang-Myeon
Park Yong-Bum
Lee Jae-Young
Jang Seung-Hun
Kim Cheol-Hong
Mo Eun-Kyung
Lee Myung-Goo
Hyun In-Gyu
Chung Ki-Suck
Choi Young-Jin
Lee Jae-Woong
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Abstract
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Background: Recently, multidrug-resistant (MDR) A. baumannii has been implicated for a significant proportion of nosocominal pneumonia in many intensive care units (ICUs), and its acquisition may increase mortality and the length of stay in the ICU. Aerosolized colistin has been successfully used in patients with cystic fibrosis, but there is a lack of data regarding the use of aerosolized colistin in patients with nosocomial pneumonia.
Methods: We conducted the present study to assess the effectiveness of aerosolized colistin for the treatment of
MDR A. baumannii nosocomial pneumonia. We retrospectively reviewed the medical records of 10 patients who had been hospitalized in the medical ICU and had received aerosolized colistin as a therapy for MDR A. baumannii pneumonia.
Results: The mean duration of aerosolized colistin therapy was 12.7±2.4 days. Nine (90%) of 10 patients showed
a favorable response to the therapy. Follow-up cultures were available for all patients, and the responsible pathogen was completely eradicated. One patient suffered from bronchospasm, which resolved after treatment with nebulized salbutamol.
Conclusion: Our results corroborate previous reports that aerosolized colistin may be an effective and safe choice
for the treatment of nosocomial pneumonia caused by MDR A. baumannii. Larger prospective controlled clinical studies are warranted to validate further the effectiveness and safety of aerosolized colistin therapy. (Tuberc Respir Dis 2008;64:102-108)
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KEYWORD
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Acinetobacter baumannii, Aerosolized colistin, Nosocomial pneumonia
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